P53959 (COG6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Conserved oligomeric Golgi complex subunit 6
Short name=COG complex subunit 6

Alternative name(s):
Complexed with DOR1 protein 2
Component of oligomeric Golgi complex 6
Protein SEC37

Gene names

Name:	COG6
Synonyms:	COD2, SEC37, TFI2
Ordered Locus Names:	YNL041C
ORF Names:	N2675

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	839 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. Ref.4 Ref.5
Subunit structure	Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8. Ref.3 Ref.4 Ref.5
Subcellular location	Golgi apparatus membrane; Peripheral membrane protein By similarity.
Miscellaneous	Present with 1720 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the COG6 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	CVT pathway Inferred from mutant phenotype PubMed 20065092. Source: SGD intra-Golgi vesicle-mediated transport Inferred from physical interaction Ref.3. Source: SGD
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell Golgi transport complex Inferred from physical interaction Ref.3. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
COG1	P53079	5	EBI-4829,EBI-4835
COG2	P53271	3	EBI-4829,EBI-16614
COG3	P40094	3	EBI-4829,EBI-16605
COG5	P53951	2	EBI-4829,EBI-4841
COG7	P53195	3	EBI-4829,EBI-4847
COG8	Q04632	5	EBI-4829,EBI-6035

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 839	839	Conserved oligomeric Golgi complex subunit 6		PRO_0000213517

Sequences

	Sequence		Length	Mass (Da)
	P53959 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 6484A40F999AD787	FASTA	839	96,976
	10 20 30 40 50 60 MDFVVDYQTY AMADTATPEL PEPEPRLNLT SDAQSQPTGK LDLQFKLPDL QRYSNNNATL 70 80 90 100 110 120 PVDNDGAGSK DLHKKMTHYA MSSIDKIQLS NPSKQLGQNS QDEKLSQQES QNFTNYEPKN 130 140 150 160 170 180 LDLSKLVSPS SGSNKNTTNL VLSNKLSKIL NNYTLINYQA TVQLRKSLKV LEENKERLSL 190 200 210 220 230 240 DEQKLMNPEY VGTLARRALR TDLESQLLKE HITVLEEFKP IIRRIKRLSS SVEKIQRTSE 250 260 270 280 290 300 KLLSNETNEV PTNNVVLQEI DQYRLKAEQL KLKKKILLSI RDRFTLNQVE DDVITNGTID 310 320 330 340 350 360 NIFFEVVKKV INIKDESSFL LTLPNLNAGN ALIMGVNEIL EKTNKKIFNY LIDFLYSFES 370 380 390 400 410 420 SSNLLNDHGT TEQESLNIFR KSLVFLSSDL ELFNELLKRV TTLRSKSILD EFLSQFDMNS 430 440 450 460 470 480 TTSKPIILSA HDPIRYIGDV LASVHSIIAN EADFVKSLFD FQDEDLKDTP ISILQQNKTF 490 500 510 520 530 540 LKGIDNKLLN DIIQSLSNSC RIRIEQIVRF EENPIINFEI VRLLKLYRVM FERKGIQDDS 550 560 570 580 590 600 SIINNLKSLE DISKNRIIGY YEDYMKQTVM AETKNSSDDL LPPEWLSEYM NKLVELFEIY 610 620 630 640 650 660 EKTHAAEDEE SEDNKLLSSK NLQTIVEQPI KDVLLKQLQT SFPLAKKNEK EKASLLTIEI 670 680 690 700 710 720 NCFDLIKSRL QPFEGLFAQD DDSRKITIWV CDKLKEYTKQ MLTLQIKFLF ENTGLDLYSN 730 740 750 760 770 780 LVNMIFPVDS VKDELDYDMY LALRDNSLME LDMVRKNVHD KLNYYLPQAL TDVQGNLLFK 790 800 810 820 830 LTSPMIADEI CDECFKKLSL FYNIFRKLLI HLYPNKKDQV FEILNFSTDE FDMLIGIDH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic." Whyte J.R., Munro S. Dev. Cell 1:527-537(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[4]	"The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins." Suvorova E.S., Duden R., Lupashin V.V. J. Cell Biol. 157:631-643(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE COG COMPLEX, FUNCTION OF THE COG COMPLEX.
[5]	"Identification of sec36p, sec37p, and sec38p: components of yeast complex that contains sec34p and sec35p." Ram R.J., Li B., Kaiser C.A. Mol. Biol. Cell 13:1484-1500(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN THE COG COMPLEX.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"The binary interacting network of the conserved oligomeric Golgi tethering complex." Loh E., Hong W. J. Biol. Chem. 279:24640-24648(2004) [PubMed] [Europe PMC] [Abstract] Cited for: COMPOSITION OF THE COG COMPLEX, INTERACTION WITH COG3 AND COG4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z71317 Genomic DNA. Translation: CAA95908.1. BK006947 Genomic DNA. Translation: DAA10504.1.
PIR	S62963.
RefSeq	NP_014357.1. NM_001182880.1.
3D structure databases
ProteinModelPortal	P53959.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4373N.
IntAct	P53959. 21 interactions.
MINT	MINT-485603.
STRING	4932.YNL041C.
Proteomic databases
PaxDb	P53959.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YNL041C; YNL041C; YNL041C.
GeneID	855687.
KEGG	sce:YNL041C.
Organism-specific databases
CYGD	YNL041c.
SGD	S000004986. COG6.
Phylogenomic databases
eggNOG	NOG291168.
GeneTree	ENSGT00390000013518.
HOGENOM	HOG000111882.
OMA	QPPEWII.
OrthoDB	EOG4TXG1B.
Gene expression databases
Genevestigator	P53959.
GermOnline	YNL041C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR010490. COG6. [Graphical view]
PANTHER	PTHR21506. PTHR21506. 1 hit.
Pfam	PF06419. COG6. 1 hit. [Graphical view]
SMART	SM01087. COG6. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	979995.

Entry information

Entry name

COG6_YEAST

Accession

Primary (citable) accession number: P53959
Secondary accession number(s): D6W1D8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program